Forms new hydroxyapatite mineral directly onto enamel surface
The effect of REGENERATE Enamel Science™ Advanced Toothpaste was assessed using a clinical in situ protocol where enamel samples were placed and maintained in the mouth for the study duration, then removed for laboratory analysis. This approach combines the advantages of sample exposure to the natural oral environment with the ability to evaluate effects using a variety of sensitive and accurate laboratory methods that are not feasible in vivo.
After twice daily brushing with Advanced Toothpaste for 4 weeks, scanning electron micrographs (SEM) consistently showed areas of hydroxyapatite mineral deposited on the enamel surface. However, new mineral formation was not seen on enamel samples brushed with fluoride-only toothpaste.
Sun Y, Li X, Deng Y, Sun JN, Tao D, Chen H, Hu Q, Liu R, Liu W, Feng X, Wang J, Carvell M, Joiner A. Mode of action studies on the formation of enamel minerals from a novel toothpaste containing calcium silicate and sodium phosphate salts. Journal of Dentistry 2014;42(Suppl 1):S30-8. READ MORE