NR-5™ TECHNOLOGY

Over 10 years of research across Unilever global centres led to the development of NR-5™ technology resulting in 5 international patents*.
*awarded and pending

REGENERATE™ ENAMEL SCIENCE WITH NR-5™ TECHNOLOGY

REGENERATE™ ENAMEL SCIENCE WITH NR-5™ TECHNOLOGY

REGENERATE™ Enamel Science Advanced Toothpaste and Advanced Enamel Serum with breakthrough NR-5™ technology, contains calcium silicate and sodium phosphate salts, which combine to form a fresh supply of enamel minerals.

Clinically proven to restore lost enamel mineral content by forming hydroxyapatite¹, the same mineral as tooth enamel. Enamel is naturally 96% hydroxyapatite.

REGENERATE™ Advanced Toothpaste for twice daily brushing, protects and strengthens against caries, for 3 times stronger teeth².

In an in-vitro study 82% of enamel mineral was regenerated after 3 days’ use of Advanced Toothpaste and Advanced Enamel Serum³.

PROVEN TO FORM HYDROXYAPATITE MINERAL

proven-to-form-hydroxyapatite-mineral

ADVANCED TOOTHPASTE

FLUORIDE-ONLY TOOTHPASTE

PROVEN TO FORM HYDROXYAPATITE MINERAL

After twice-daily brushing with Advanced Toothpaste for 4 weeks, scanning electron micrographs showed hydroxyapatite-mineral layers deposited onto the enamel surface. In contrast, when enamel samples were brushed with fluoride-only toothpaste no deposits were observed.

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PROVEN IDENTICAL CRYSTAL STRUCTURE AND CHEMICAL COMPOSITION TO ENAMEL

proven-identical-crystal-structure-and-chemical-composition-to-enamel

PROVEN IDENTICAL CRYSTAL STRUCTURE AND CHEMICAL COMPOSITION TO ENAMEL

Microscopy and spectroscopy data demonstrated that the new hydroxyapatite has identical crystal structure and chemical composition to enamel mineral.

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PROVEN TO REMINERALISE 82% OF ENAMEL AFTER 3 DAYS³

proven-to-remineralise-82%--of-enamel-after-3-days³

In-vitro assessment of remineralisation of acid-softened enamel samples showed that the REGENERATE™ Enamel Science system provides significant recovery of enamel hardness after 3 days.

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SUPERIOR RECOVERY OF ENAMEL HARDNESS

superior-recovery-of-enamel-hardness

Clinically proven to provide superior enamel re-hardening after 3 days’ combined use of REGENERATE™ Advanced Toothpaste and Advanced Enamel Serum compared with a standard fluoride toothpaste.

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SUPERIOR PROTECTION AGAINST ENAMEL EROSION

superior-protection-against-enamel-erosion

After 7 days’ application and frequent acid challenges, the combined use of REGENERATE™ Advanced Toothpaste and Advanced Enamel Serum showed two times greater protection from erosion than a fluoride-only toothpaste.

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LEARN MORE ABOUT NR-5™ TECHNOLOGY

learn-more-about-nr-5™-technology

LEARN MORE ABOUT NR-5™ TECHNOLOGY

Unilever is committed to scientific research in the field of enamel erosion. Watch this space to stay up-to-date with the very latest evidence. Download a summary booklet containing all the studies that support NR-5™ technology. 

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¹Acts on early invisible stages of enamel erosion. Helps to regenerate enamel by restoring its mineral content and microhardness with regular use. Clinically proven.
²In vitro test measuring enamel hardness versus a standard fluoride toothpaste.
³Based on an in vitro test measuring enamel surface microhardness after 3 days’ combined use of Advanced Toothpaste and Advanced Enamel Serum
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